PUM2 inhibits ferroptosis and enhances oxaliplatin resistance in COAD via the NEDD4L/NRF2 axis
Jiacheng Xie, Kai Dong, Jialin Wu, Xinsheng Cheng, Shikai Wang, Hongzhen Zhang · 2026
Read PUM2 inhibits ferroptosis and enhances oxaliplatin resistance in COAD via the NEDD4L/NRF2 axis by Jiacheng Xie, Kai Dong, Jialin Wu, Xinsheng Cheng, Shikai Wang, Hongzhen Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311146.txt.
Description
Jiacheng Xie and co-authors study an RNA binding protein that shields colon cancer from chemo in a 2026 paper. Colon cancer kills many people yearly, and oxaliplatin based care often fails as resistance grows. Iron driven cell death offers a bypass, yet tumor guards can block that death route.
The protein PUM2 binds and mutes a helper gene message, which lets a guard protein pile up and block iron death. Tumors with high PUM2 thus shrug off oxaliplatin. In mouse models, pairing oxaliplatin with a guard blocker restored strong tumor control. The chain gives clinics a target pair for resistant disease.
Catalog record
| CREATOR | Jiacheng Xie, Kai Dong, Jialin Wu, Xinsheng Cheng, Shikai Wang, Hongzhen Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39945 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |