Tandem single-cell epigenetic and transcriptomic analysis reveals spatiotemporally distinct genomic features among testis cell lineages
Mustika Rahmawati, Tia M Hoisington, Blanca Lopez-Biladeau, Kanako Hayashi, Nathan C Law · 2026
Read Tandem single-cell epigenetic and transcriptomic analysis reveals spatiotemporally distinct genomic features among testis cell lineages by Mustika Rahmawati, Tia M Hoisington, Blanca Lopez-Biladeau, Kanako Hayashi, Nathan C Law (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311140.txt.
Description
Mustika Rahmawati and colleagues pair gene activity with chromatin maps in single mouse testis cells in a 2026 study. Testis growth joins sperm line and support line paths that mature on split schedules. How open chromatin guides each path was unclear, so matched single nucleus data were built from embryo to newborn stages.
Germ cells opened chromatin at far regions tied to stem cell genes. Support cells inside tubules differed from those in the outlet zone. Outer tissue cells showed split fates marked by key drivers. Signal codes and cell talk maps added context. Distinct timing may guide infertility study.
Catalog record
| CREATOR | Mustika Rahmawati, Tia M Hoisington, Blanca Lopez-Biladeau, Kanako Hayashi, Nathan C Law |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73112 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |