Integrated genomic and immunophenotypic profiling reveals monoclonal origin, smoking-driven evolution and heterogeneous microenvironment in pulmonary adenosquamous carcinoma
Xiuwen Zhang, Heng Wu, Wenhao Zhao, Zixuan Hu, Guannan Wang, Yongwen Li, Xuanguang Li, Hongbing Zhang, Minghui Liu, Chen Chen, Jinghao Liu, Wenhao Zhou, Hongyu Liu, Jun Chen · 2026
Read Integrated genomic and immunophenotypic profiling reveals monoclonal origin, smoking-driven evolution and heterogeneous microenvironment in pulmonary adenosquamous carcinoma by Xiuwen Zhang, Heng Wu, Wenhao Zhao, Zixuan Hu, Guannan Wang, Yongwen Li, Xuanguang Li, Hongbing Zhang, Minghui Liu, Chen Chen, Jinghao Liu, Wenhao Zhou, Hongyu Liu, Jun Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311056.txt.
Description
Xiuwen Zhang and a large team profile a rare mixed lung cancer at gene and immune levels in a 2026 study. Pulmonary adenosquamous cancer holds both gland and squamous parts and acts aggressively, yet its origin and drivers were unclear. Clinical data and tissue gene tests were joined.
Care data covered 76 patients, and nine tumors were split into matched gland and squamous zones for gene reading. Shared trunk mutations and copy changes point to a single cell origin for both parts. Smokers held higher mutation loads and distinct mutation marks. Gland zones drew far more immune cells than squamous zones, which may shape drug response.
Catalog record
| CREATOR | Xiuwen Zhang, Heng Wu, Wenhao Zhao, Zixuan Hu, Guannan Wang, Yongwen Li, Xuanguang Li, Hongbing Zhang, Minghui Liu, Chen Chen, Jinghao Liu, Wenhao Zhou, Hongyu Liu, Jun Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41511 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |