Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions
Yusuf Aggour, Roberto Salguero-Gómez · 2026
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Description
Yusuf Aggour and Roberto Salguero-Gómez propose a layered frame for judging anti aging plans in a 2026 paper. Aging science has deep facts on cell hallmarks but no shared frame that joins evolution views with practical scoring of new plans. Their Aging Onion sorts aging traits into layers along two broad axes.
One axis tracks growth programs that stay on too long, and the other tracks weak upkeep of body tissue. Food sensing serves as the first test field, with calorie limits as a broad benchmark and rapamycin as a narrow drug contrast. The axes help explain why the two plans differ in reach. Wider tests must show the frame holds.
Catalog record
| CREATOR | Yusuf Aggour, Roberto Salguero-Gómez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93910 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |