Targeting nuclear receptors in muscular dystrophies and regenerative myogenesis
Eira Mann, Hoang Vu, Vihang A. Narkar, Yu Liu · 2026
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Description
Eira Mann and colleagues review nuclear receptors as drug targets in muscle disease in a 2026 paper. Muscle can regrow through resident stem cells, yet inherited dystrophies bring steady loss, swelling, and weak repair. Receptors that sense hormones and food signals control gene programs for energy, swelling, and new muscle growth.
Faulty receptor action helps drive wasting in many muscle ills, while tuned action may guard energy, calm swelling and scarring, and spur regrowth. The review maps each receptor family role in healthy and sick muscle. Gaps in human proof and tissue targeting block clinic use, so next steps are charted.
Catalog record
| CREATOR | Eira Mann, Hoang Vu, Vihang A. Narkar, Yu Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55133 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |