When mitochondria lose their fold: matrix proteostasis and stress signaling
Nils Bertram, Dejana Mokranjac · 2026
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Description
Nils Bertram and Dejana Mokranjac discuss protein quality control inside mitochondria in a 2026 review. Mitochondria make energy and build key cell parts, yet most of their proteins arrive from outside and must fold correctly in a tight inner space. Helper and cutting proteins guide import, folding, and disposal.
When the system is swamped, faulty proteins clump together. Some clumps aid recovery, some wall off harm, and some turn toxic. Stress inside mitochondria also sends signals to the rest of the cell that reshape defense. Knowing how clumps form and how alarms spread may clarify many diseases tied to faulty proteins.
Catalog record
| CREATOR | Nils Bertram, Dejana Mokranjac |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35342 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |