Early brain‐penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1‐related Aicardi‐Goutières syndrome
Russell C Dale, Jessica Hayes, Velda X Han, Ruwani Dissanayake, Xianzhong Lau, Michelle Farrar, Brian Gloss, Markus Hofer, Esther Tantsis, Michelle Lorentzos, Safiyyah Abbas, Yanick J Crow, Shekeeb Mohammad, Shrujna Patel · 2026
Read Early brain‐penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1‐related Aicardi‐Goutières syndrome by Russell C Dale, Jessica Hayes, Velda X Han, Ruwani Dissanayake, Xianzhong Lau, Michelle Farrar, Brian Gloss, Markus Hofer, Esther Tantsis, Michelle Lorentzos, Safiyyah Abbas, Yanick J Crow, Shekeeb Mohammad, Shrujna Patel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13310790.txt.
Description
Russell C Dale led a 2026 case report on early brain reaching immune care for a baby with Aicardi-Goutières syndrome. The rare gene disease drives excess interferon signals that harm the brain. Fast gene testing found two faults in the ADAR1 gene, and past data showed most such children face severe disability or death.
Care began at 11 months with pulsed steroid doses every three weeks plus a daily JAK blocking drug. By 24 months the child crawled and took a few steps alone, far ahead of past norms. Blood cell tests showed interferon signals reversed after three months of care. Which drug drove the change stays unclear.
Catalog record
| CREATOR | Russell C Dale, Jessica Hayes, Velda X Han, Ruwani Dissanayake, Xianzhong Lau, Michelle Farrar, Brian Gloss, Markus Hofer, Esther Tantsis, Michelle Lorentzos, Safiyyah Abbas, Yanick J Crow, Shekeeb Mohammad, Shrujna Patel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23837 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |