Activation of BK channels ameliorates cardiac injury Via NFκB-NLRP3 signaling in angiotensin II-induced hypertension mouse model
Long Zhao, Xingchen Wu, Xiaomao Luo, Anwen Zheng, Qiang Yue, Haidong Wang, Junko Ishida, Cesar A. Romero, Douglas C. Eaton, Janet D. Klein, Xiaonan H. Wang, Yan Xu, Hui Cai · 2026
Read Activation of BK channels ameliorates cardiac injury Via NFκB-NLRP3 signaling in angiotensin II-induced hypertension mouse model by Long Zhao, Xingchen Wu, Xiaomao Luo, Anwen Zheng, Qiang Yue, Haidong Wang, Junko Ishida, Cesar A. Romero, Douglas C. Eaton, Janet D. Klein, Xiaonan H. Wang, Yan Xu, Hui Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13310761.txt.
Description
Long Zhao and colleagues test a potassium channel opener in mice with drug induced high blood pressure in a 2026 study. Long pressure harms the heart by thickening and scarring its walls, which can lead to heart failure. Channels that help blood vessels relax were lower in sick hearts, so the team asked if boosting them would protect the heart.
Mice got a pressure raising drug for four weeks, with or without the channel opener. Treated mice showed lower pressure, less scarring, and less cell stress. In lab immune cells, the opener calmed a signal chain that drives swelling. Results point to a new target for pressure related heart harm.
Catalog record
| CREATOR | Long Zhao, Xingchen Wu, Xiaomao Luo, Anwen Zheng, Qiang Yue, Haidong Wang, Junko Ishida, Cesar A. Romero, Douglas C. Eaton, Janet D. Klein, Xiaonan H. Wang, Yan Xu, Hui Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43167 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |