Circular RNAs as molecular bridges: dual regulation of ferroptosis and immunity in cancer
Songbai Xu, Peiyi Liang, Tie Lin, Guangxin Zhang, Xiying Fu, Yicun Wang · 2026
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Description
Songbai Xu and co-authors review circular RNAs as dual regulators of iron-driven cell death and anti-tumor immunity in a 2026 article. Circular RNAs are looped RNA molecules prized for stability and tissue-specific patterns. Ferroptosis, a death route driven by iron and fat oxidation, interacts tightly with the tumor immune setting.
Loops can sponge small RNAs, scaffold proteins, and even encode small peptides, letting one loop touch both death and immunity nodes at once, a pattern the authors name dual regulation. Three major crosstalk routes are mapped in detail, with inflammatory signals passing both ways. The review weighs how loop-based drugs might force tumor death while waking immune attack, and what blocks that plan today.
Catalog record
| CREATOR | Songbai Xu, Peiyi Liang, Tie Lin, Guangxin Zhang, Xiying Fu, Yicun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17933 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |