Proliferative glomerulonephritis with monoclonal immunoglobulin IgG1-κ deposition in a patient with type 1 diabetes: a case report and literature review
Xi Li, Xiaoyan Zhang, Xinjun Dai, Yan Zhang, Tian Lan, Jian Li, Minghui Wu, Tianhang Jia, Jie Li · 2026
Read Proliferative glomerulonephritis with monoclonal immunoglobulin IgG1-κ deposition in a patient with type 1 diabetes: a case report and literature review by Xi Li, Xiaoyan Zhang, Xinjun Dai, Yan Zhang, Tian Lan, Jian Li, Minghui Wu, Tianhang Jia, Jie Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13310675.txt.
Description
Xi Li and co-authors report a rare monoclonal kidney disease in a young woman with diabetes in a 2026 case article. In proliferative glomerulonephritis with monoclonal deposits, a single antibody clone coats the kidney filters, causing swelling, protein loss, and kidney failure. No standard treatment protocol exists.
The 30-year-old had lived with type 1 diabetes for 19 years with poor control, and arrived with a week of nausea, vomiting, and whole-body swelling. Tests showed nephrotic-range protein loss, low blood protein, anemia, acute kidney and heart failure. Biopsy after stabilizing care showed diffuse IgG deposits of a single light chain type. The authors use the case to push biopsy and clone checks in fast-declining diabetic kidneys.
Catalog record
| CREATOR | Xi Li, Xiaoyan Zhang, Xinjun Dai, Yan Zhang, Tian Lan, Jian Li, Minghui Wu, Tianhang Jia, Jie Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30007 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |