Omics landscapes of hepatic echinococcosis: bulk foundations, emerging single-cell studies, and analytical considerations
Qianwen Wang, Xiaopeng Wang, Honglin Yan, Jingping Yuan · 2026
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Description
Qianwen Wang and co-authors review gene profiling of liver echinococcosis in a 2026 article. The disease is a parasitic cyst or infiltrating growth in the liver, driven by tapeworm larvae in farming regions. Lesions persist for years through a stalemate of immune control, vessel growth, and scarring, whose cell-level drivers stay fuzzy.
Bulk gene studies mapped broad shifts in immune, vessel, and matrix programs but averaged signals across mixed tissue. Single-cell and spatial methods now resolve which cells do what and where they sit. Early cell studies flag expanding macrophage types, tired T cells, and vessel-friendly myeloid cells near lesions. The authors set standards for future cell-level work and warn where bulk habits mislead.
Catalog record
| CREATOR | Qianwen Wang, Xiaopeng Wang, Honglin Yan, Jingping Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38607 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |