Vacuolar Protein Sorting 35 Controls Hepatocellular Proliferation Through SRC Signaling and Promotes Diethyl Nitrosamine–Induced Tumor Initiation
Markus G Barbosa, Dyonne Y Vos, Cristy RC Verzijl, Andries H Heida, Marco Bakker, Niels J Kloosterhuis, Mirjam H Koster, Marieke Smit, Alba Fajardo, Dicky Struik, Peter Olinga, Johan W Jonker, Rachel Thomas, Albert Pol, Vincent E de Meijer, Anna Moles, Umesh Tharehalli, Jan Albert Kuivenhoven, Bart · 2026
Read Vacuolar Protein Sorting 35 Controls Hepatocellular Proliferation Through SRC Signaling and Promotes Diethyl Nitrosamine–Induced Tumor Initiation by Markus G Barbosa, Dyonne Y Vos, Cristy RC Verzijl, Andries H Heida, Marco Bakker, Niels J Kloosterhuis, Mirjam H Koster, Marieke Smit, Alba Fajardo, Dicky Struik, Peter Olinga, Johan W Jonker, Rachel Thomas, Albert Pol, Vincent E de Meijer, Anna Moles, Umesh Tharehalli, Jan Albert Kuivenhoven, Bart (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13310651.txt.
Description
Markus Barbosa and co-authors study, in 2026, a protein sorting factor that may drive liver cancer growth. Liver cancer is a leading cause of cancer death, and treatment options are limited. The factor, part of the cell's cargo sorting machinery, had been flagged as a possible cancer gene, but its role in starting liver tumors was unclear.
The team made mice whose livers lack the factor and tracked cell growth in young and older animals and during regrowth after surgery. A cancer-causing chemical was used to start tumors. Without the factor, liver cells grew faster through a known growth signal, and tumor initiation changed. The work maps an early step in this cancer.
Catalog record
| CREATOR | Markus G Barbosa, Dyonne Y Vos, Cristy RC Verzijl, Andries H Heida, Marco Bakker, Niels J Kloosterhuis, Mirjam H Koster, Marieke Smit, Alba Fajardo, Dicky Struik, Peter Olinga, Johan W Jonker, Rachel Thomas, Albert Pol, Vincent E de Meijer, Anna Moles, Umesh Tharehalli, Jan Albert Kuivenhoven, Bart |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |