XRCC1 deficiency drives telomeric chromatin leakage, inflammatory signalling and senescence
Anna Piscone, Francesca Gorini, Susanna Ambrosio, Carmen Caiazza, Giannicola Marotta, Anna Noviello, Giovanni Di Fusco, Giovanni Scala, Barbara Majello, Stefano Amente · 2026
Read XRCC1 deficiency drives telomeric chromatin leakage, inflammatory signalling and senescence by Anna Piscone, Francesca Gorini, Susanna Ambrosio, Carmen Caiazza, Giannicola Marotta, Anna Noviello, Giovanni Di Fusco, Giovanni Scala, Barbara Majello, Stefano Amente (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13310650.txt.
Description
Anna Piscone and co-authors study what happens when a DNA repair scaffold protein goes missing in breast cells in a 2026 article. Oxygen-driven DNA damage constantly threatens the genome, and the base excision repair path fixes the most common lesions. Two of its factors, APE1 and XRCC1, also steady the copying machinery.
Matched breast cell models lacking each factor were compared at rest and under oxidative stress. XRCC1 loss, more than APE1 loss, raised damage signaling and pushed chromatin fragments, rich in telomere DNA, into the cell body. Those cells also switched on an internal alarm path, inflammatory signaling, and aging traits. The authors name XRCC1 a key guard against stray DNA and float it as a treatment lever.
Catalog record
| CREATOR | Anna Piscone, Francesca Gorini, Susanna Ambrosio, Carmen Caiazza, Giannicola Marotta, Anna Noviello, Giovanni Di Fusco, Giovanni Scala, Barbara Majello, Stefano Amente |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78330 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |