The Genetics of Atrial Fibrillation: From Molecular Mechanisms to Precision Medicine
Dilip D Hinge, Abhijeet Shelke, Ramesh Kawade, Satish Patil · 2026
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Description
Dilip D Hinge, Abhijeet Shelke, Ramesh Kawade, and Satish Patil map the genetics of atrial fibrillation in 2026, the commonest sustained heart rhythm disorder. Family studies suggest genes account for a large share of risk, especially in early-onset cases. The review organises disease genes into four functional groups and weighs variant prevalence and penetrance for each.
One group covers faulty ion channels that govern the heart's electrical signals. A second covers structural proteins of the muscle and its scaffolding. Transcription factors that shape heart development form the third group, and calcium-handling proteins the fourth. Despite differing jobs, these defects converge on shared electrical and structural weaknesses in the atria. Understanding which module a patient's variant sits in could guide targeted therapy. The authors frame genetics as the route from blanket treatment toward precision cardiology.
Catalog record
| CREATOR | Dilip D Hinge, Abhijeet Shelke, Ramesh Kawade, Satish Patil |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |