The effect of P2RX7 functional SNPs on osteoblast cell phenotype, function and signalling- roles in bone homeostasis and osteogenesis
Luke Tattersall, Qiguang Wang, Anna Lisa Giuliani, Elena Adinolfi, Alison Gartland · 2026
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Description
Luke Tattersall examines how variants of a cell sensor shape bone cell behavior in a 2026 study. The sensor, P2RX7, responds to ATP, a molecule plentiful around bone, and helps govern bone balance. Natural variants and shortened forms of the sensor can strengthen or weaken its action.
Full and shortened sensor forms, alone and paired, plus three single-letter variants, were placed into bone-forming cells. Calcium entry, pore opening, cell growth, enzyme activity, mineral laying, and bone gene activity were all measured. Variant effects differed by form and pairing, with known gain and loss variants behaving distinctly. The author uses the pattern to explain how inherited sensor differences may shift bone mass and turnover.
Catalog record
| CREATOR | Luke Tattersall, Qiguang Wang, Anna Lisa Giuliani, Elena Adinolfi, Alison Gartland |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54822 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |