Spheroids and organoids to study long noncoding RNAs in cancer: how they could replace animal models
Ana Maria Capela, João Pessoa, Hugo Arede, Bruno Bernardes de Jesus · 2026
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Description
Ana Maria Capela and colleagues ask in a 2026 review whether ball-like and organ-like cell clusters can stand in for animals in cancer research. The test case is long noncoding RNA, genetic material that does not build proteins but steers cell behavior. Such clusters sit between flat cell cultures and live animals in complexity.
Raising or silencing select RNAs in tumor clusters changed cluster size and growth in the same direction seen in mouse tumors. Clusters cost less and can carry a patient own tumor traits. Animal work still matters for spread and survival questions. The authors argue clusters can cover growth checks, letting animal use shrink to the questions clusters cannot answer.
Catalog record
| CREATOR | Ana Maria Capela, João Pessoa, Hugo Arede, Bruno Bernardes de Jesus |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 129380 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |