AmpC β-Lactamases in SPICE (Serratia, Pseudomonas, Indole-Positive Proteus, Citrobacter, Enterobacter) Organisms: A Rising Threat to Antimicrobial Therapy
Prajakta S Jadhav, Priyanka M Mane, Satish Patil · 2026
Read AmpC β-Lactamases in SPICE (Serratia, Pseudomonas, Indole-Positive Proteus, Citrobacter, Enterobacter) Organisms: A Rising Threat to Antimicrobial Therapy by Prajakta S Jadhav, Priyanka M Mane, Satish Patil (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13309091.txt.
Description
Prajakta Jadhav, Priyanka Mane, and Satish Patil review in 2026 a resistance enzyme family that weakens antibiotic treatment in a feared group of Gram-negative germs. The group, gathered under the SPICE acronym, carry AmpC beta-lactamases that chew through many penicillins and cephalosporins. Older blocker drugs barely touch these enzymes.
The review covers how the enzymes work, where they spread, how labs detect them, and which treatments remain. Newer blockers such as avibactam and relebactam do act against many AmpC makers, which muddies simple treatment rules. Genes for the enzymes can sit on the cell's own DNA or travel on plasmids between germs. Reading an AmpC maker as beatable invites treatment failure in serious cases. The authors call for sharper tracking, faster tests, and tighter drug care to slow a threat they describe as rising.
Catalog record
| CREATOR | Prajakta S Jadhav, Priyanka M Mane, Satish Patil |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |