Disseminated Tuberculosis With Presumptive Tricuspid Valve Endocarditis Presenting as Culture-Negative Infective Endocarditis: A Clinical Diagnostic Challenge
Shaurya Tewari, Shrikanth Jantli, Mahadev Meena, Sagar Khadanga · 2026
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Description
Shaurya Tewari and colleagues present in 2026 a thirty-four-year-old man from a high tuberculosis region of Madhya Pradesh. His three months of fever, night sweats, and weight loss hid an unusual heart infection. Blood cultures stayed sterile despite broad antibiotics, and a new heart murmur prompted an ultrasound scan. The tricuspid valve showed flail leaflets with growths typical of endocarditis.
Bone marrow tissue held granulomas, and body scans revealed swollen necrotic lymph nodes, liver granulomas, and lung nodules. A rapid molecular test on lung washings found drug-sensitive tuberculosis bacilli. Standard four-drug tuberculosis therapy plus steroids made him fever-free within a week. The valve itself could never be sampled, so the heart diagnosis stays presumptive. The authors urge clinicians in endemic regions to consider tuberculosis when endocarditis cultures come back empty.
Catalog record
| CREATOR | Shaurya Tewari, Shrikanth Jantli, Mahadev Meena, Sagar Khadanga |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |