Integrated in silico and in vivo larvicidal evaluation of compounds targeting juvenile hormone for malaria vector control
Eric Kibagendi Osoro, Adeniyi Ayinde Abdulwahab, Florence Ezinwa Nkemehule, Adedoyin John-Joy Owolade, Micheal Abimbola Oladosu, Wilberforce K. Ndarawit, Daramola Oluwasegun Oluwatobiloba, Moses Adondua Abah, Fidelis Ngugi, Njogu M. Kimani, Damilola Samuel Bodun · 2026
Read Integrated in silico and in vivo larvicidal evaluation of compounds targeting juvenile hormone for malaria vector control by Eric Kibagendi Osoro, Adeniyi Ayinde Abdulwahab, Florence Ezinwa Nkemehule, Adedoyin John-Joy Owolade, Micheal Abimbola Oladosu, Wilberforce K. Ndarawit, Daramola Oluwasegun Oluwatobiloba, Moses Adondua Abah, Fidelis Ngugi, Njogu M. Kimani, Damilola Samuel Bodun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13308820.txt.
Description
Eric Kibagendi Osoro and co-authors screen in 2026 farm chemicals for mosquito larva killers that jam a juvenile hormone binding protein in malaria vectors. They sifted 2874 compounds in a computer flow, docked the best to the target, and ran energy, likeness, hazard, and motion checks.
Fifteen leads bound as tightly as the known partner lodged in the target, by the energy scores in this screen. Two leads stood out for snug fit and steady grip in motion runs over time. In live larva tests those two killed half the group at 37.75 and 33.49 parts per million in the doses used. Both merit wider field and safety checks.
Catalog record
| CREATOR | Eric Kibagendi Osoro, Adeniyi Ayinde Abdulwahab, Florence Ezinwa Nkemehule, Adedoyin John-Joy Owolade, Micheal Abimbola Oladosu, Wilberforce K. Ndarawit, Daramola Oluwasegun Oluwatobiloba, Moses Adondua Abah, Fidelis Ngugi, Njogu M. Kimani, Damilola Samuel Bodun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67347 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |