Local oxygen tension dictates hematopoietic cell growth and potency
James Ropa, Sarah Gutch, Lindsay Wathen, So Jeong Kim, Jimin Park, Jessica Newton, Gracie Whitacre, Arafat Aljoufi, Scott Cooper, Wouter Van’t Hof, Mark H Kaplan, Maegan L Capitano · 2026
Read Local oxygen tension dictates hematopoietic cell growth and potency by James Ropa, Sarah Gutch, Lindsay Wathen, So Jeong Kim, Jimin Park, Jessica Newton, Gracie Whitacre, Arafat Aljoufi, Scott Cooper, Wouter Van’t Hof, Mark H Kaplan, Maegan L Capitano (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13308678.txt.
Description
A large team of stem cell researchers asks how the amount of oxygen around blood-forming stem cells shapes what those cells become. These stem and early progenitor cells supply a lifetime of blood and immune cells and are used in cell therapy. The team grew cells from cord blood, bone marrow, and mobilized blood under high and low oxygen and compared how they grew.
Cells already committed to a blood line grew faster in high oxygen, while the most primitive cells, including ones able to rebuild blood in the body, were kept better in low oxygen. Gene activity studies showed the expected oxygen-sensing programs at work and pointed to new markers, including PRSS2, tied to cell strength. Low oxygen kept cells quieter and less stressed. The findings suggest that tuning oxygen could improve cell therapies.
Catalog record
| CREATOR | James Ropa, Sarah Gutch, Lindsay Wathen, So Jeong Kim, Jimin Park, Jessica Newton, Gracie Whitacre, Arafat Aljoufi, Scott Cooper, Wouter Van’t Hof, Mark H Kaplan, Maegan L Capitano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |