Reading the tumour at single-cell resolution: Original research in the Precision Therapeutics special issue

Description

Mohammad Asim introduces a 2026 virtual special issue of Translational Oncology built around reading tumours cell by cell. Twenty-eight peer-reviewed papers make up the collection, and the editorial treats the single review separately from twenty-seven original studies. Cancers covered range across gut, lung, kidney, brain, skin, bone, and blood.

Methods run from single-cell mapping and combined omics to laboratory perturbation studies and drug discovery driven by systems pharmacology. One strand builds cell atlases of tumour surroundings and squeezes them into survival signatures. Another anchors computer findings in tissue staining and animal models before claims are made. A clinical strand embeds biomarker analysis inside a randomised phase three trial. Asim arranges the papers along a discovery-to-clinic path. The issue's promise, he argues, is measurement precise enough to change individual patient decisions.

Catalog record

Source: https://europepmc.org/articles/PMC13308507