A candidate-variant association study of self-reported asthma in mothers of the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort
Alvin E. Lirio, Jing Chen, Paulita Duazo, Nanette Lee, Linda Adair, Martin D. Tobin, Catherine John, Anna L. Guyatt · 2026
Read A candidate-variant association study of self-reported asthma in mothers of the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort by Alvin E. Lirio, Jing Chen, Paulita Duazo, Nanette Lee, Linda Adair, Martin D. Tobin, Catherine John, Anna L. Guyatt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13308225.txt.
Description
Alvin E Lirio and co-authors run in 2026 the first gene study of asthma in a Filipino group, testing known variants in mothers from the Cebu survey cohort. Among 1678 unrelated mothers, 129 told of asthma, and 27 variants drawn from large global studies were checked one by one and as a joint score.
One variant in the SMAD3 gene passed the strict bar, with an odds ratio of 1.80 for asthma in this group. The joint score also tracked with higher odds, though the gain per step was small in size. Small numbers barred a full genome scan, so the authors call for more cohorts in groups that gene studies have long skipped over.
Catalog record
| CREATOR | Alvin E. Lirio, Jing Chen, Paulita Duazo, Nanette Lee, Linda Adair, Martin D. Tobin, Catherine John, Anna L. Guyatt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22007 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |