Exosomes from mesenchymal stem/stromal cells and their therapeutic role in osteoarthritic pain
Dimitrios Kouroupis, Stanislava Jergova, Jacqueline Sagen, Thomas M. Best · 2026
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Description
Dimitrios Kouroupis and co-authors review in 2026 tiny parcels called exosomes that stem cells release, and their promise for easing pain from worn joints. Knee osteoarthritis touches about 500 million people worldwide, and pain plus stiffness drive much of the burden for those who live with it.
Joint fat and lining tissue feed swelling and send pain signals through agents such as substance P and CGRP. Exosomes can carry calming signals into that setting without placing live cells in the joint. The review weighs how such parcels might quiet nerve driven swelling and protect joint balance, while noting that dose, targeting, and proof in patients still need much more work.
Catalog record
| CREATOR | Dimitrios Kouroupis, Stanislava Jergova, Jacqueline Sagen, Thomas M. Best |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15889 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |