Lactylation‐Related Genes in Ulcerative Colitis: A Multiomics Mendelian Randomization Study for Therapeutic Target Discovery
Na An, Ruiyun Wang, Huiping Jiao, Zhongwen Lu, Yafei Dou, Laikun Zheng, Zhaoliang Ding · 2026
Read Lactylation‐Related Genes in Ulcerative Colitis: A Multiomics Mendelian Randomization Study for Therapeutic Target Discovery by Na An, Ruiyun Wang, Huiping Jiao, Zhongwen Lu, Yafei Dou, Laikun Zheng, Zhaoliang Ding (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13307184.txt.
Description
Na An hunted drug targets for ulcerative colitis among lactylation genes in a 2026 genetics study. Starting from 46 such genes, overlap with blood gene-control data narrowed the field to 29 candidates for causal testing.
Outcome data covered 482,657 participants in a Finnish database in the reported design. Multiple causal models, a second validation method, corrected expression data and single-cell profiles from a public set all filtered the list. A cell model using inflamed colon lining then checked how shortlisted genes change during inflammation. The short list gives drug hunters fresh leads for calm gut drugs with clear gene roots.
Catalog record
| CREATOR | Na An, Ruiyun Wang, Huiping Jiao, Zhongwen Lu, Yafei Dou, Laikun Zheng, Zhaoliang Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38118 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |