Pharmacokinetics and Tissue Distribution of Fluorescently Labeled Neoagarotetraose in Mice
Nan Wu, Chaocheng Wu, Yating Du, Zhuhua Chan, Runying Zeng · 2026
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Description
A sugar chain from seaweed, called NA4, shows anti-inflammatory promise, but a pill only works if the gut lets it through. Five authors attached a near-infrared dye to the molecule and tracked it in mice after feeding and after injection, measuring levels in blood and organs over time.
Fed mice absorbed it fast, peaking in blood at one hour, and it lingered, with a half-life near nine hours. At one day, the label sat mostly in kidney, liver, and lung. Imaging caught intact molecules crossing the gut wall into the body. Injected doses stayed in a small volume and cleared faster, as expected. The authors conclude the sugar crosses the intestine in whole form and reaches the blood, supporting its development as an orally taken agent with organ-leaning distribution.
Catalog record
| CREATOR | Nan Wu, Chaocheng Wu, Yating Du, Zhuhua Chan, Runying Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |