Design and Preliminary In Vivo Evaluation of J2H-1802, a Hybrid Compound Derived from 5-ASA and MMF, in a DSS-Induced Colitis Mouse Model
Myong Jin Lee, Sung-Hoon Park, Gabsik Yang, Jason Kim, Ju Young Lee, Kwanghyun Choi, Kiwon Jung, Ji Hwan Lee, Sumi Lee, Woo-Chan Son, Ki Sung Kang · 2026
Read Design and Preliminary In Vivo Evaluation of J2H-1802, a Hybrid Compound Derived from 5-ASA and MMF, in a DSS-Induced Colitis Mouse Model by Myong Jin Lee, Sung-Hoon Park, Gabsik Yang, Jason Kim, Ju Young Lee, Kwanghyun Choi, Kiwon Jung, Ji Hwan Lee, Sumi Lee, Woo-Chan Son, Ki Sung Kang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13305943.txt.
Description
Myong Jin Lee and a large team test a new hybrid compound, J2H-1802, in mice with chemically induced colitis in a 2026 study. The molecule joins features of mycophenolate mofetil and 5-aminosalicylic acid, two drugs used against inflammation. Colitis was triggered with dextran sulfate sodium for seven days before oral treatment began.
Treated mice lost less weight, had less diarrhoea and bleeding, and scored lower on a disease activity index. Their colons stayed longer and their spleens less swollen than in untreated animals. Inflammatory signals in colon tissue, including tumour necrosis factor and interleukin-6, fell under treatment. A signalling route involving nuclear factor-kappa B and cyclooxygenase-2 was also quieted. The authors present the hybrid as a scaffold worth refining for bowel inflammation.
Catalog record
| CREATOR | Myong Jin Lee, Sung-Hoon Park, Gabsik Yang, Jason Kim, Ju Young Lee, Kwanghyun Choi, Kiwon Jung, Ji Hwan Lee, Sumi Lee, Woo-Chan Son, Ki Sung Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |