Post-Translational Modifications Modulate the HLA-DR3 Restricted Epitope Landscape of Sjögren’s Associated Autoantigens
Danmeng Li, Alexandria Voigt, Cuong Q. Nguyen · 2026
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Description
Danmeng Li, Alexandria Voigt, and Cuong Q. Nguyen explore, in a 2026 study, how chemical edits to self-proteins change what the immune system displays in Sjögren's disease. The illness attacks tear and saliva glands and is strongly tied to one immune presenter molecule, HLA-DR3. Edits called post-translational modifications can create new targets on familiar proteins.
Computer predictions said edits at key anchor points usually weakened binding to the presenter rather than improving it. Scanning three known target proteins found crowded clusters of editable anchors in particular folded regions. Lab tests on selected edited peptides then showed stronger T cell responses paired with tighter binding. Structural models revealed a slightly shifted fit with a larger contact surface, hinting how tolerance breaks.
Catalog record
| CREATOR | Danmeng Li, Alexandria Voigt, Cuong Q. Nguyen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |