NLRP3 Inflammasome and IL-1–Mediated Inflammation in Human Carotid Atherosclerosis: A Systematic Review of Endarterectomy-Based Evidence
David Mendonça-Soares, Antónia Rocha-Melo-Sousa, Mohammed Shahat, Cármen Tavares, Lina Carvalho, Vitor Sá-Martins, Manuel Neiva-Sousa, Mariana Fragão-Marques, João Rocha Neves · 2026
Read NLRP3 Inflammasome and IL-1–Mediated Inflammation in Human Carotid Atherosclerosis: A Systematic Review of Endarterectomy-Based Evidence by David Mendonça-Soares, Antónia Rocha-Melo-Sousa, Mohammed Shahat, Cármen Tavares, Lina Carvalho, Vitor Sá-Martins, Manuel Neiva-Sousa, Mariana Fragão-Marques, João Rocha Neves (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13304386.txt.
Description
David Mendonça-Soares and co-authors systematically review, in a 2026 paper, the NLRP3 inflammasome as a marker of dangerous neck-artery plaques. This molecular alarm triggers interleukin-1 release, and unstable plaques cause strokes when they rupture. Studies of tissue removed during carotid surgery offered the most direct evidence.
Sixteen studies with 1,677 participants were pooled narratively because methods differed too much for statistics. Alarm components and interleukin family members ran consistently higher in unstable plaques and in patients with symptoms. The markers tracked with bleeding inside plaques, big fatty cores, and heavy immune cell invasion. Links to later heart events were hinted but weakly proven, since few studies adjusted properly for other risks.
Catalog record
| CREATOR | David Mendonça-Soares, Antónia Rocha-Melo-Sousa, Mohammed Shahat, Cármen Tavares, Lina Carvalho, Vitor Sá-Martins, Manuel Neiva-Sousa, Mariana Fragão-Marques, João Rocha Neves |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |