roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells and impair longevity
Kai-Le Li, Chen Wang, Yong-Hao Li, Bo Peng, Li Zheng, Qinyun Che, Xin-Yi Lu, Donglin Li, Yu-Tong Li, Hui-Min Wei, Jian-Feng Chang, Wen-Fei Wang, Mengmeng Liu, Xiangnan Li, Fangfang Jin, Kai Liu, Yabin Li, Li-Wei Liu, Mingyang Li, Jian-Quan Ni, Ting Xie, Fang-Lin Sun · 2026
Read roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells and impair longevity by Kai-Le Li, Chen Wang, Yong-Hao Li, Bo Peng, Li Zheng, Qinyun Che, Xin-Yi Lu, Donglin Li, Yu-Tong Li, Hui-Min Wei, Jian-Feng Chang, Wen-Fei Wang, Mengmeng Liu, Xiangnan Li, Fangfang Jin, Kai Liu, Yabin Li, Li-Wei Liu, Mingyang Li, Jian-Quan Ni, Ting Xie, Fang-Lin Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13303914.txt.
Description
Kai-Le Li and co-authors study two long noncoding RNAs in fruit fly gut stem cells in this 2026 paper. The RNAs, roX1 and roX2, are known for their role in male flies' X chromosome control. Their work in females had never been explored.
In female gut stem cells, infection or aging raised these RNAs. They pulled in proteins that pack DNA into heterochromatin, which shuts genes down. More packing meant wider gene repression in stem and daughter cells. Raising the RNAs drove excess stem cell growth, while blocking them eased gut decline and lengthened life. A similar RNA in humans rose with age in their checks.
Catalog record
| CREATOR | Kai-Le Li, Chen Wang, Yong-Hao Li, Bo Peng, Li Zheng, Qinyun Che, Xin-Yi Lu, Donglin Li, Yu-Tong Li, Hui-Min Wei, Jian-Feng Chang, Wen-Fei Wang, Mengmeng Liu, Xiangnan Li, Fangfang Jin, Kai Liu, Yabin Li, Li-Wei Liu, Mingyang Li, Jian-Quan Ni, Ting Xie, Fang-Lin Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |