Clinical potential of fluid-based biomarkers for recurrent implantation failure: a systematic review
Mojtaba Moradi, Leilani L. Santos, Wei Zhou, Ellen Menkhorst, Evdokia Dimitriadis · 2026
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Description
Blood tests built from several markers outperform any single one for diagnosing recurrent implantation failure, Mojtaba Moradi and colleagues conclude in a 2026 systematic review. Eighteen studies survived screening of more than three thousand records across four databases. Blood, uterine fluid, and menstrual fluid were all in scope, though blood studies dominated the haul.
Immune-cell profiling panels and cytokine-plus-clinical models reached diagnostic accuracy up to 0.94 on the AUC scale. Lone markers sagged, one lymphocyte count managing only 0.577. A single uterine-fluid study showed promise, and menstrual fluid had none at all. The authors want prospective validation in standardized cohorts before clinics adopt any panel.
Catalog record
| CREATOR | Mojtaba Moradi, Leilani L. Santos, Wei Zhou, Ellen Menkhorst, Evdokia Dimitriadis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54775 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |