Relationship Between Adipose Tissue and Liver Dysfunction in Women with Polycystic Ovary Syndrome and Metabolic Syndrome
Sebastião Freitas de Medeiros, Gustavo Arantes Rosa Maciel · 2026
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Description
Sebastião Freitas de Medeiros and Gustavo Arantes Rosa Maciel review, in a 2026 narrative review, the two-way chemical conversation between fat tissue and the liver in women with polycystic ovary syndrome. The syndrome commonly travels with belly fat, insulin resistance, and metabolic syndrome. Signals released by fat and liver cells may drive much of that overlap.
Excess belly fat floods the liver with fatty acids, fuelling toxicity, oxidative stress, and inflammation there. Liver-made signals such as fetuin-A run abnormally high and track with insulin resistance and fatty liver progression. Fat-made signals including resistin and chemerin add inflammation and hormone disturbance, while a falling adiponectin-to-leptin balance worsens matters. The authors frame this crosstalk as a target for earlier risk detection.
Catalog record
| CREATOR | Sebastião Freitas de Medeiros, Gustavo Arantes Rosa Maciel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |