The Forgotten Gate: Choroid Plexus and Blood-CSF Barrier in Arboviral Encephalitis
Cecília M. Wodzik, Matheus Henrique B. Figueiredo, Paula S. Nakamura, Mônica Rodrigues F. Machado, Vivaldo G. da Costa, Rafael M. da Costa, Marielena V. Saivish · 2026
Read The Forgotten Gate: Choroid Plexus and Blood-CSF Barrier in Arboviral Encephalitis by Cecília M. Wodzik, Matheus Henrique B. Figueiredo, Paula S. Nakamura, Mônica Rodrigues F. Machado, Vivaldo G. da Costa, Rafael M. da Costa, Marielena V. Saivish (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13302637.txt.
Description
Cecília M. Wodzik and co-authors argue, in a 2026 perspective, that a forgotten gateway into the brain deserves attention in mosquito- and tick-borne viral encephalitis. Research has centred on the blood-brain barrier, yet the choroid plexus, which makes spinal fluid, forms its own blood-to-fluid barrier. The authors grade what is known virus by virus.
Direct support is strongest for Zika virus, where experiments show the tissue's cells becoming infected and virus reaching the nervous system along the fluid route. Semliki Forest virus adds limited direct support of its own. For West Nile, Japanese encephalitis, and tick-borne encephalitis viruses, proof of this route stays indirect or missing. The authors urge adding the second barrier to invasion models rather than replacing the first.
Catalog record
| CREATOR | Cecília M. Wodzik, Matheus Henrique B. Figueiredo, Paula S. Nakamura, Mônica Rodrigues F. Machado, Vivaldo G. da Costa, Rafael M. da Costa, Marielena V. Saivish |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |