Clinical Trials in Older Adults with Cardiovascular Multimorbidity: A Perspective on Pragmatic Trial Design
Clara Bonanad, Didier Sánchez-Ospina, Sergio García-Blas, Gonzalo Luis Alonso-Salinas, Pedro Cepas-Guillén, Sergio Raposeiras-Roubín, Diego Segura-Rodríguez, Javier Pérez-Cervera, Carolina Ortiz-Cortés, Miguel Corbí-Pascual, Alicia Noguerón-García, Claudio M. Rivadulla-Varela, María Thiscal López-Ll · 2026
Read Clinical Trials in Older Adults with Cardiovascular Multimorbidity: A Perspective on Pragmatic Trial Design by Clara Bonanad, Didier Sánchez-Ospina, Sergio García-Blas, Gonzalo Luis Alonso-Salinas, Pedro Cepas-Guillén, Sergio Raposeiras-Roubín, Diego Segura-Rodríguez, Javier Pérez-Cervera, Carolina Ortiz-Cortés, Miguel Corbí-Pascual, Alicia Noguerón-García, Claudio M. Rivadulla-Varela, María Thiscal López-Ll (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13302622.txt.
Description
Clara Bonanad and a large group of colleagues argue, in a 2026 perspective, that heart trials still exclude the very older patients who fill real clinics. Two recent European trials enrolling older adults with several illnesses at once are dissected as case studies. The authors propose a framework for heart care in old age, named COMGERCARDIO.
Both trials earned credit for deliberately including such patients, yet shared recurring weaknesses. Frailty was acknowledged but rarely measured with a full old-age assessment, and safety rules may still have filtered in only robust patients. Outcome rankings did not always match what patients value most, and treatments stayed drug-focused and single-discipline. The framework adds baseline frailty scoring, care adapted to each patient's limits, and outcome rankings centred on patients.
Catalog record
| CREATOR | Clara Bonanad, Didier Sánchez-Ospina, Sergio García-Blas, Gonzalo Luis Alonso-Salinas, Pedro Cepas-Guillén, Sergio Raposeiras-Roubín, Diego Segura-Rodríguez, Javier Pérez-Cervera, Carolina Ortiz-Cortés, Miguel Corbí-Pascual, Alicia Noguerón-García, Claudio M. Rivadulla-Varela, María Thiscal López-Ll |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |