Comparison of mechanical/optical and microfluidic electrochemical point-of-care ACT systems during transseptal ablation under continuous anticoagulation
K Krieger, A Wutzler · 2026
Read Comparison of mechanical/optical and microfluidic electrochemical point-of-care ACT systems during transseptal ablation under continuous anticoagulation by K Krieger, A Wutzler (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13302438.txt.
Description
K Krieger and A Wutzler published a 2026 comparison of two bedside devices that measure activated clotting time during heart ablation procedures. Clotting time guides heparin dosing, and the two systems work on different principles, one detecting clots mechanically and optically, the other using a microfluidic electrochemical cartridge. The study asked whether their readings can be treated as interchangeable during transseptal ablation.
Thirty patients on continued oral anticoagulants contributed 55 paired measurements taken at the same moments. The mechanical and optical system read higher by an average of 61.5 seconds, a gap the paired test found highly consistent. At a 250 second safety threshold, the two devices judged very different shares of patients adequately treated, 90 percent against 46.6 percent in the comparison. The authors warn that a single cutoff applied across devices risks too little or too much anticoagulation.
Catalog record
| CREATOR | K Krieger, A Wutzler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |