Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation: a reconstructed patient level meta-analysis
L Barbosa, V M R Oliveira, B R Nascimento, C Pisani, M I Scanavacca, F Darrieux · 2026
Read Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation: a reconstructed patient level meta-analysis by L Barbosa, V M R Oliveira, B R Nascimento, C Pisani, M I Scanavacca, F Darrieux (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13302317.txt.
Description
L Barbosa and co-authors pool patient-level data in a 2026 meta-analysis on when to start blood thinners after a stroke in patients with atrial fibrillation. Starting early might prevent another clot, yet it could also provoke bleeding in freshly damaged brain tissue. Four randomised trials have tested early against later starts.
The pooled set held 6,642 patients, about half assigned to early treatment with modern oral anticoagulants. Rates of the combined outcome, covering repeat stroke, brain bleeding, and unclassified stroke within ninety days, did not differ significantly between strategies. Separate looks at repeat stroke, brain bleeding, and body-wide clots told the same story. The authors conclude that neither timing proved superior and call for more trials.
Catalog record
| CREATOR | L Barbosa, V M R Oliveira, B R Nascimento, C Pisani, M I Scanavacca, F Darrieux |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |