Cardiopulmonary exercise testing in patients with CACNA1C-associated LQTS
V Leitermann, A Lee, M J Bos, M J Ackerman, T G Allison · 2026
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Description
V Leitermann and co-authors examine exercise testing safety in a 2026 study of a rare inherited rhythm disorder tied to the CACNA1C gene. This form of long QT syndrome stretches the heart's electrical recovery and can cause cardiac arrest, sometimes in early childhood. Families face hard questions about safe physical activity.
Eight genetically confirmed patients completed nineteen exercise tests in total, all while taking beta-blocker medicine. Fitness levels averaged modestly below predicted values, and a few patients showed stray extra beats during testing. One patient showed frequent extra beats with short runs of fast rhythm, yet nobody fainted or arrested across all tests. The authors conclude that supervised testing on treatment appears safe and that exercise should be encouraged.
Catalog record
| CREATOR | V Leitermann, A Lee, M J Bos, M J Ackerman, T G Allison |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |