Amplatzer-Based Transcatheter Paravalvular Leak Closure: A Narrative Review of Device Design, Procedural Strategy, Safety, and Outcomes
Andrei Mihnea Rosu, Claudiu Ungureanu, Emanuel Stefan Radu, Maria-Daniela Tanasescu, Eduard George Cismas, Oana Andreea Popa · 2026
Read Amplatzer-Based Transcatheter Paravalvular Leak Closure: A Narrative Review of Device Design, Procedural Strategy, Safety, and Outcomes by Andrei Mihnea Rosu, Claudiu Ungureanu, Emanuel Stefan Radu, Maria-Daniela Tanasescu, Eduard George Cismas, Oana Andreea Popa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13300935.txt.
Description
Andrei Mihnea Rosu and co-authors review catheter closure of paravalvular leaks with Amplatzer devices in a 2026 narrative review. These leaks around replacement heart valves can cause heart failure and blood cell destruction, and reopening the chest is risky after earlier surgery. The authors walk through device design, imaging guided strategy, and the registry and cohort evidence for a device family prized for fitting irregular, crescent shaped defects.
Reported results show high technical success with real relief of symptoms and hemolysis, plus reasonable medium term durability in well chosen patients. Outcomes still hinge on leak shape, the prosthesis involved, access route, imaging quality, and operator experience. The evidence base has no randomized trials, uses inconsistent outcome definitions, and rarely compares devices head to head over long periods. Even so, the authors keep Amplatzer platforms as a practical mainstay for complex leaks in experienced centers.
Catalog record
| CREATOR | Andrei Mihnea Rosu, Claudiu Ungureanu, Emanuel Stefan Radu, Maria-Daniela Tanasescu, Eduard George Cismas, Oana Andreea Popa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |