Extrachromosomal DNA Amplification as a Prognostic Factor for Cancer
Filip Gajewski, Joanna Pec, Jakub Kleinrok, Weronika Pająk, Katarzyna Pacyna, Agata Tokarzewska, Paweł Krawczyk · 2026
Read Extrachromosomal DNA Amplification as a Prognostic Factor for Cancer by Filip Gajewski, Joanna Pec, Jakub Kleinrok, Weronika Pająk, Katarzyna Pacyna, Agata Tokarzewska, Paweł Krawczyk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13300797.txt.
Description
Rogue circles of DNA floating outside chromosomes may forecast how a cancer will behave, Filip Gajewski and colleagues argue in a 2026 review. These extrachromosomal elements carry heavy loads of growth genes such as EGFR, MYC, MDM2, and CDK4. Detection routes covered include FISH, whole-genome sequencing, and reconstruction software across many tumor types.
Because the circles lack centromeres, daughter cells inherit uneven shares, which speeds tumor diversity and drug resistance. Surveys find them often in glioblastoma, liposarcoma, and HER2-positive breast cancer, and their presence tracks with poorer outcomes. The authors back ecDNA as a risk marker, while warning that no standard, scalable test yet exists for routine care.
Catalog record
| CREATOR | Filip Gajewski, Joanna Pec, Jakub Kleinrok, Weronika Pająk, Katarzyna Pacyna, Agata Tokarzewska, Paweł Krawczyk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47516 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |