In Vitro Evaluation of Olorofim and Amphotericin B Combination Therapy Against Talaromyces marneffei
Le Hoang Ngoc Lan, Heera Natesan Sambath, Lottie Brown, Nguyen Thi Mai Thu, Shawin Vitsupakorn, Phan Thi Ha My, Dang Hoang Khanh, Nguyen Thi Thu Hoai, Ngo Thi Hoa, Thuy Le · 2026
Read In Vitro Evaluation of Olorofim and Amphotericin B Combination Therapy Against Talaromyces marneffei by Le Hoang Ngoc Lan, Heera Natesan Sambath, Lottie Brown, Nguyen Thi Mai Thu, Shawin Vitsupakorn, Phan Thi Ha My, Dang Hoang Khanh, Nguyen Thi Thu Hoai, Ngo Thi Hoa, Thuy Le (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13300783.txt.
Description
Two antifungals that attack a deadly fungus in different ways do not necessarily help each other, Le Hoang Ngoc Lan and colleagues find in a 2026 laboratory study. They paired olorofim, a new drug that blocks pyrimidine building, with the membrane-targeting amphotericin B against Talaromyces marneffei. Checkerboard tests covered fifty-five clinical isolates from talaromycosis cases.
Every pairing scored as indifferent, with interaction indices between just above 0.5 and 1.03, so no synergy appeared. Time-kill tests matched: amphotericin B killed in a dose-dependent way, while olorofim only held growth back. The authors doubt olorofim will strengthen opening therapy, but see a possible place for it in later consolidation treatment.
Catalog record
| CREATOR | Le Hoang Ngoc Lan, Heera Natesan Sambath, Lottie Brown, Nguyen Thi Mai Thu, Shawin Vitsupakorn, Phan Thi Ha My, Dang Hoang Khanh, Nguyen Thi Thu Hoai, Ngo Thi Hoa, Thuy Le |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30897 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |