The Potential Role of Vitamin D in BRCA1 Pathogenic Variant Carriers: A Narrative Review
Joanna Robaczyńska, Milena Kiljańczyk, Maciej Maj, Adam Kiljańczyk, Tomasz Byrski, Cezary Cybulski, Izabela Janiuk, Jacek Gronwald, Jan Lubiński · 2026
Read The Potential Role of Vitamin D in BRCA1 Pathogenic Variant Carriers: A Narrative Review by Joanna Robaczyńska, Milena Kiljańczyk, Maciej Maj, Adam Kiljańczyk, Tomasz Byrski, Cezary Cybulski, Izabela Janiuk, Jacek Gronwald, Jan Lubiński (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13300645.txt.
Description
Could a common vitamin soften the cancer risk carried by BRCA1 mutations? Joanna Robaczyńska and colleagues weigh the evidence in a 2026 narrative review. Carriers face high lifetime risks of breast and ovarian cancer, and vitamin D touches cell growth, immune control, and the DNA repair paths that BRCA1 defects disrupt.
The review gathers molecular work on calcitriol signaling through its receptor, then turns to the sparse human data in carriers themselves. Findings so far remain thin and inconsistent, with no firm proof that raising vitamin D levels changes outcomes for this group. The authors mark out clear gaps and argue for targeted studies before any preventive advice is given.
Catalog record
| CREATOR | Joanna Robaczyńska, Milena Kiljańczyk, Maciej Maj, Adam Kiljańczyk, Tomasz Byrski, Cezary Cybulski, Izabela Janiuk, Jacek Gronwald, Jan Lubiński |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35132 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |