Systematic Worldwide Review on the Performance of Non-Invasive Exhalation-Based Methods for the Diagnosis of Liver Fibrosis
Jeel Moya-Salazar, Gianella S. Liviapoma-Rojas, Carlos Aliaga-Refulio, Eliane A. Goicochea-Palomino, Maria Jesús Moya-Salazar, Marx E. Morales-Martinez, Dante Espinoza-Morriberrón · 2026
Read Systematic Worldwide Review on the Performance of Non-Invasive Exhalation-Based Methods for the Diagnosis of Liver Fibrosis by Jeel Moya-Salazar, Gianella S. Liviapoma-Rojas, Carlos Aliaga-Refulio, Eliane A. Goicochea-Palomino, Maria Jesús Moya-Salazar, Marx E. Morales-Martinez, Dante Espinoza-Morriberrón (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13300345.txt.
Description
Jeel Moya-Salazar and co-authors present a 2026 systematic review of breath based tests for liver fibrosis. Diagnosis usually rests on biopsy, an invasive procedure often done late, so the authors compared studies that detect volatile organic compounds in exhaled breath instead. Searches across thirteen databases followed PRISMA guidelines, and study quality was graded with the PEDro scale.
Only seven investigations met the inclusion rules, all from Europe and all in adults. Gas chromatography with mass spectrometry was the most common technique, used in four studies, while electronic nose devices appeared in two. Sensitivity mostly ranged from 85 to 100 percent, and three studies passed ninety percent specificity. Isoprene emerged as the most consistent breath marker. The authors ask for more work in regions where liver fibrosis risk and prevalence run high.
Catalog record
| CREATOR | Jeel Moya-Salazar, Gianella S. Liviapoma-Rojas, Carlos Aliaga-Refulio, Eliane A. Goicochea-Palomino, Maria Jesús Moya-Salazar, Marx E. Morales-Martinez, Dante Espinoza-Morriberrón |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |