Lineage-Dependent Regulation of Glutathione Homeostasis by EAAC1 and GTRAP3-18 During Differentiation of Mesenchymal Stem Cells into Neuron-like Cells
Nobuko Matsumura, Wattanaporn Bhadhprasit, Koji Aoyama · 2026
Read Lineage-Dependent Regulation of Glutathione Homeostasis by EAAC1 and GTRAP3-18 During Differentiation of Mesenchymal Stem Cells into Neuron-like Cells by Nobuko Matsumura, Wattanaporn Bhadhprasit, Koji Aoyama (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13300276.txt.
Description
How stem cells guard their glutathione supply changes as they turn toward neurons, Nobuko Matsumura and colleagues show in a 2026 cell study. Working with mouse bone-marrow mesenchymal stem cells and neuron-like cells derived from them, the team tracked the cysteine transporter EAAC1 and its brake protein, GTRAP3-18.
Undifferentiated stem cells held more glutathione yet kept EAAC1 mostly off the cell surface, while the derived neuron-like cells relied on it more directly. Removing GTRAP3-18 lowered glutathione in stem cells but raised both EAAC1 and glutathione in neuron-like cells. The split shows redox control is rewired by lineage, a point that matters for stem-cell therapies aimed at nerve repair.
Catalog record
| CREATOR | Nobuko Matsumura, Wattanaporn Bhadhprasit, Koji Aoyama |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41205 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |