Synergistic Induction of Caspase-8-Mediated Leukaemic Cell Death by Fisetin and Pinocembrin
Narawan Kaewthawee, Ankita Sharma, James Michael Brimson, Sirikalaya Brimson · 2026
Read Synergistic Induction of Caspase-8-Mediated Leukaemic Cell Death by Fisetin and Pinocembrin by Narawan Kaewthawee, Ankita Sharma, James Michael Brimson, Sirikalaya Brimson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13300158.txt.
Description
Two plant flavonoids, fisetin and pinocembrin, kill leukaemia cells more strongly together than alone, report Narawan Kaewthawee and colleagues in a 2026 laboratory study. The team tested the pair on Jurkat and K562 cell lines, tracking survival, programmed death, and cell-cycle proteins, with computer docking against the Fas receptor.
Fisetin alone cut viability and switched on caspase-8, a marker of death-receptor signaling, while lowering CDK4. A Fas-blocking compound confirmed the receptor's role in the effect. Adding pinocembrin produced synergy scores above 10 in Jurkat cells and sharpened caspase-8 activation. In K562 cells, the pairing also shrank colony growth in soft agar far more than either compound by itself.
Catalog record
| CREATOR | Narawan Kaewthawee, Ankita Sharma, James Michael Brimson, Sirikalaya Brimson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66381 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |