Lipid Metabolism Reprogramming in the Aging Brain: Glial-Mediated Pathogenic Mechanisms and Translational Strategies in Neurodegeneration
Wei Shao, Kai Wang, Yongchao Liu, Haojia Zhang, Zijin Sun, Rui Zhou · 2026
Read Lipid Metabolism Reprogramming in the Aging Brain: Glial-Mediated Pathogenic Mechanisms and Translational Strategies in Neurodegeneration by Wei Shao, Kai Wang, Yongchao Liu, Haojia Zhang, Zijin Sun, Rui Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13300150.txt.
Description
Fat makes up about half the dry weight of the brain, and Wei Shao and five colleagues argue in a 2026 review that drifting lipid balance helps drive age-related brain disease. The authors place glial cells at the center of the story, with neurons as partners rather than sole actors.
They trace APOE-linked faults in cholesterol transport, lipid droplets that strain microglia, and ceramide paths that push neurons toward death. The same networks are then mapped onto Alzheimer's disease, Parkinson's disease, and demyelinating disorders. Closing sections weigh food-based steps, LXR and RXR agonist drugs, nanoparticle delivery past the blood–brain barrier, and lipid profiling as an early warning tool.
Catalog record
| CREATOR | Wei Shao, Kai Wang, Yongchao Liu, Haojia Zhang, Zijin Sun, Rui Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68505 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |