Integrative Transcriptomic Analysis and Single-Cell Validation Identify a Six-Hub-Gene Signature Converging on Inflammatory Signaling in Osteoarthritis
Xueya Lv, Yang Yu, Jiawen Fan, Lianjiang Guo, Xiang Zhu, Xingye Li · 2026
Read Integrative Transcriptomic Analysis and Single-Cell Validation Identify a Six-Hub-Gene Signature Converging on Inflammatory Signaling in Osteoarthritis by Xueya Lv, Yang Yu, Jiawen Fan, Lianjiang Guo, Xiang Zhu, Xingye Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13300059.txt.
Description
Six genes tied to inflammation may help flag osteoarthritis, according to a 2026 computational study led by Xueya Lv. The team merged three public cartilage gene-expression datasets and corrected for batch effects before hunting for genes that separate diseased from healthy tissue. Single-cell data then checked where the candidate genes are active.
Fifty-eight genes differed between groups, mostly turned down, and six hub genes formed a diagnostic model with fair accuracy. Virtual knockouts of five hubs disturbed IL-17, NF-κB, and chemokine pathways, pointing to a shared inflammatory core. Clustering also split patients into two subtypes with different stress-response activity. The signature could guide diagnosis and future drug studies.
Catalog record
| CREATOR | Xueya Lv, Yang Yu, Jiawen Fan, Lianjiang Guo, Xiang Zhu, Xingye Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29201 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |