PXDN, TCF4 and TSPAN7 Are Differentially Expressed in B-Cell Acute Lymphoblastic Leukaemia: An Integrative Analysis
Pasquale Primo, Francesco Cecere, Alessandra Cianflone, Fiorenza Mastrodonato, Giovanna Maisto, Luigi Coppola, Giovanna Giagnuolo, Fara Petruzziello, Luigi Vitagliano, Rosanna Parasole, Giuseppe Menna, Peppino Mirabelli · 2026
Read PXDN, TCF4 and TSPAN7 Are Differentially Expressed in B-Cell Acute Lymphoblastic Leukaemia: An Integrative Analysis by Pasquale Primo, Francesco Cecere, Alessandra Cianflone, Fiorenza Mastrodonato, Giovanna Maisto, Luigi Coppola, Giovanna Giagnuolo, Fara Petruzziello, Luigi Vitagliano, Rosanna Parasole, Giuseppe Menna, Peppino Mirabelli (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13299483.txt.
Description
Three genes stand out in childhood leukemia when two large datasets are read together, report Pasquale Primo and colleagues in a 2026 integrative analysis. They examined PXDN, TCF4, and TSPAN7 expression across a microarray cohort and a pediatric RNA sequencing collection in acute lymphoblastic leukemia.
TCF4 and PXDN were consistently switched up in B-cell disease, while TSPAN7 ran higher in T-cell disease and varied in B-cell cases; initial lab checks in patient samples agreed. Network modeling linked the first two genes to developmental pathways and the third to nerve-lineage programs. The authors present the trio as candidates for sorting patients and for future drug targeting, pending experimental proof.
Catalog record
| CREATOR | Pasquale Primo, Francesco Cecere, Alessandra Cianflone, Fiorenza Mastrodonato, Giovanna Maisto, Luigi Coppola, Giovanna Giagnuolo, Fara Petruzziello, Luigi Vitagliano, Rosanna Parasole, Giuseppe Menna, Peppino Mirabelli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33751 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |