Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c-Myc/Ccnd1 axis
Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang · 2026
Read Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c-Myc/Ccnd1 axis by Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13299234.txt.
Description
Dialing down one mitochondrial protein, but not too far, coaxes heart muscle cells back into dividing, show Ying Gao and colleagues in a 2026 study. The protein is NDUFA13, a cog in the cell's main energy complex, whose levels shift as young hearts lose their regenerative window.
Moderate reduction in mice and cultured cells raised cell-cycle gene activity, shrank scarring, and improved recovery after the heart tip was surgically removed. The cells also burned more sugar through glycolysis while keeping mitochondrial function, and that metabolic shift raised c-Myc, which switched on the cyclin D1 gene to drive division. The authors flag the pathway as a regeneration target.
Catalog record
| CREATOR | Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51135 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |