Towards modeling phage therapy
Rob J. de Boer, Robert Schooley, Alan S. Perelson, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder · 2026
Read Towards modeling phage therapy by Rob J. de Boer, Robert Schooley, Alan S. Perelson, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13298995.txt.
Description
Math can guide the design of virus cocktails that hunt drug-resistant bacteria, argue Rob J de Boer and colleagues in a 2026 modeling paper. They extended a mouse-calibrated model to human phage therapy, where several bacterial strains and several phages interact and resistance keeps evolving.
Fitting the model to one successful human case, they found success hinged on how resistant the bacteria already were before treatment and on giving diverse cocktails early. Once a good cocktail was in place, fine-tuning infection rates mattered little. Resistant strains surged as sensitive ones fell. Their prescription: hit hard and early with a varied set of phages to raise the barrier against resistance.
Catalog record
| CREATOR | Rob J. de Boer, Robert Schooley, Alan S. Perelson, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder, Roland Regoes, James Faeder |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 112483 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |