Novel insights into the histopathological characteristics of immune checkpoint inhibitor-related myocarditis
Tatsuya Nishikawa, Tomoyuki Otani, Hironori Yamamoto, Taku Yasui, Motohiro Shingu, Yuto Osumi, Kenta Ishibashi, Yoshihiko Ikeda, Akiko Nonaka, Yuko Fukuda, Ryosuke Murai, Yutaka Furukawa, Shigeo Hara, Daigo Sawaki, Noritoshi Hiranuma, Yoshitaka Ohashi, Tomofumi Takaya, Yujiro Asada, Natsuko Ishii, T · 2026
Read Novel insights into the histopathological characteristics of immune checkpoint inhibitor-related myocarditis by Tatsuya Nishikawa, Tomoyuki Otani, Hironori Yamamoto, Taku Yasui, Motohiro Shingu, Yuto Osumi, Kenta Ishibashi, Yoshihiko Ikeda, Akiko Nonaka, Yuko Fukuda, Ryosuke Murai, Yutaka Furukawa, Shigeo Hara, Daigo Sawaki, Noritoshi Hiranuma, Yoshitaka Ohashi, Tomofumi Takaya, Yujiro Asada, Natsuko Ishii, T (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13298878.txt.
Description
Tatsuya Nishikawa and a large team look under the microscope at heart inflammation caused by cancer immunotherapy. Checkpoint drugs can inflame the heart muscle, a rare but deadly side effect. Tissue checks are the main way to confirm it, yet firm evidence is thin. Their 2026 study gathers 38 patients from many centers. Biopsy grades sort the cases by a published scale.
Higher grades held more T cells and macrophages in the muscle. Two tissue marks proved keen spotters of inflammation. Other marks flagged only the worst grades. Both bulk counts and hot-spot counts were used to grade the cell rush. The team aims to sharpen biopsy reading so risky cases are caught and graded the same way everywhere.
Catalog record
| CREATOR | Tatsuya Nishikawa, Tomoyuki Otani, Hironori Yamamoto, Taku Yasui, Motohiro Shingu, Yuto Osumi, Kenta Ishibashi, Yoshihiko Ikeda, Akiko Nonaka, Yuko Fukuda, Ryosuke Murai, Yutaka Furukawa, Shigeo Hara, Daigo Sawaki, Noritoshi Hiranuma, Yoshitaka Ohashi, Tomofumi Takaya, Yujiro Asada, Natsuko Ishii, T |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |