The Role of AKR1B1 in Diabetic Nephropathy: A Genetic Association Study and Meta-Analysis
Maria Tziastoudi, Christos Cholevas, Efthimios Dardiotis, Evangelia E. Tsironi, Maria Divani, Theodoros Eleftheriadis, Ioannis Stefanidis · 2026
Read The Role of AKR1B1 in Diabetic Nephropathy: A Genetic Association Study and Meta-Analysis by Maria Tziastoudi, Christos Cholevas, Efthimios Dardiotis, Evangelia E. Tsironi, Maria Divani, Theodoros Eleftheriadis, Ioannis Stefanidis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13298859.txt.
Description
Maria Tziastoudi and colleagues study a gene variant's link to diabetic kidney disease through a Greek case-control study plus meta-analysis, in a 2026 genetics paper. The AKR1B1 gene has been tied to high-glucose kidney damage. Five variants were typed in patients with nephropathy, diabetic patients without it, and healthy controls.
The Greek cohort alone showed no significant association for any variant. Pooling published studies changed the picture: one promoter variant linked to nephropathy when compared against diabetic controls, and a repeat variant mattered in Asian and type 2 subgroups. The authors argue control choice shapes conclusions, and the gene may influence progression rather than diabetes itself.
Catalog record
| CREATOR | Maria Tziastoudi, Christos Cholevas, Efthimios Dardiotis, Evangelia E. Tsironi, Maria Divani, Theodoros Eleftheriadis, Ioannis Stefanidis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |